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Chromatin Dynamics Regulation Lab
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The lab explores what makes living things life-like through molecular fluctuation and cell-to-cell variability.
AboutAbout the lab
Seeing what makes life life-like in fluctuation and variability.
The Chromatin Dynamics Regulation Lab conducts research with a focus on the "life-likeness" of living things, such as molecular fluctuation and cell-to-cell variability.
Believing that living bodies have mechanisms that tolerate and even make use of fluctuation and variability to respond to environmental change, the lab investigates them by integrating biochemical and mathematical approaches.
Its main research topics include regulation of chromatin dynamics in the genome damage response, epigenomic analysis of cellular senescence signaling, and elucidation of chromatin regulatory mechanisms in energy metabolism.
It is a field within the Graduate School of Biostudies, and students join the lab at the graduate level.
Key terms
- Chromatin
- A structure in the cell nucleus in which DNA is wound around proteins and folded.
- Epigenome
- The whole set of marks that determine which genes are active and to what extent, without changing the DNA sequence itself.
- Single-cell analysis
- A method of separating cells one by one and examining the molecules and gene activity within each.
ResearchResearch themes
Likening the living body to a machine made of molecules and clarifying life phenomena such as cell proliferation and differentiation at the molecular level has become one trend in biochemistry and molecular biology. Meanwhile, this lab focuses on the molecular fluctuation and cell-to-cell variability that have come into view, and explores the mechanisms behind the life-like nature of organisms.
View More ↗MembersFaculty
- Associate ProfessorTsuyoshi Ikura
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