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Harada Lab
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The lab explores how cancer recurs and metastasizes, starting from the hypoxic environment inside tumors.
AboutAbout the lab
Approaching the mechanisms of treatment resistance in cancer.
The Harada Lab (Cancer Cell Biology) studies the mechanisms by which cancer recurs and metastasizes.
Inside a tumor there are diverse microenvironments, including regions lacking oxygen and nutrients, and it is becoming clear that some cancer cells within them acquire resistance to radiotherapy and malignant traits.
Focusing on HIF-1, which is responsible for adaptation to hypoxia, the lab aims to clarify these mechanisms and lead to the establishment of new treatments.
It is a field within the Graduate School of Biostudies, and students join the lab at the graduate level.
Key terms
- Intratumoral microenvironment
- The environment inside a tumor, encompassing the blood vessels and other cells around cancer cells, as well as oxygen and nutrient conditions.
- Resistance to radiotherapy
- A property in which cancer cells are less likely to die even when irradiated.
- HIF-1
- Hypoxia-inducible factor 1. It is activated in cells exposed to hypoxia and is responsible for adaptation to a hypoxic environment.
ResearchResearch themes
Within the diverse and complex microenvironments of malignant tumors, it is becoming clear that some cancer cells acquire resistance to radiotherapy and malignant traits, causing cancer recurrence and metastasis. With the keywords "intratumoral microenvironment," "tumor radiobiology," and "hypoxia biology," the lab aims to clarify these mechanisms and lead to the establishment of new treatments.
Mechanisms of Recurrence After Radiotherapy
A 2012 paper presented direct evidence that cancer cells in the hypoxic environment inside tumors survive radiotherapy and, with the help of HIF-1, lead to recurrence. The lab is tackling the question of where cancer recurrence originates.
New Genes That Activate HIF-1
To clarify how cancer cells become more malignant under hypoxia, the lab is searching for new genes that regulate HIF-1 activity. So far, it has found IDH3 and UCHL1 as new genes that activate HIF-1.
MembersFaculty
The members of the Harada Lab consist of faculty, part-time researchers, academic support staff, secretaries, students in the doctoral and master's programs, and collaborators.As of 2025
- ProfessorHiroshi Harada
- Associate ProfessorJin-Min Nam
- Program-Specific Assistant ProfessorMinoru Kobayashi
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