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Carlton Lab
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Using C. elegans, the lab investigates how chromosomes pair up during meiosis.
AboutAbout the lab
Tracking how chromosomes meet and part under the microscope
The Carlton Lab studies how chromosomes behave during meiosis, the cell division that produces sperm and eggs.
Using C. elegans as a model organism, the lab investigates the molecular mechanisms that control chromosome behavior, mainly through genetics and microscopy.
In humans, errors in meiosis lead to infertility and congenital chromosomal abnormalities.
With many international students, the lab offers an international environment where students learn research and English at the same time, and it is recruiting graduate students.
Key terms
- Meiosis
- The cell division that produces germ cells such as sperm and eggs, in which the number of chromosomes is halved
- Homologous chromosomes
- A pair of chromosomes of the same type carrying the same genes, one inherited from the mother and one from the father
- Crossover
- The physical linkage of homologous chromosomes through the exchange of parts of their DNA
- C. elegans
- A small animal used as a model organism in meiosis research, rich in oocytes
NewsLab news
A student won an Oral Presentation Award at the meeting on creating the future of C. elegans research
A student won the Best Poster Presentation Award at the department's international symposium
A student won an Oral Presentation Award at BSS, the department's student symposium
A student won an Oral Presentation Award at the Kansai C. elegans Meeting
A student's paper was accepted by Current Biology
ResearchResearch themes
Meiosis is a special cell division that produces haploid gametes such as sperm and eggs from diploid precursor cells. Using C. elegans, a model organism rich in oocytes, the lab aims to understand the molecular mechanisms that control chromosome behavior during meiosis.
How Chromosomes Find Their Homologous Partners
The lab studies how, in meiotic prophase, each chromosome distinguishes its homologous partner from among many chromosomes and pairs with it. Much about this recognition mechanism remains unknown.
Just the Right Amount of DNA Breaks
To create crossovers between homologous chromosomes, chromosomes undergo DNA double-strand breaks to initiate recombination. Too few breaks prevent crossovers from forming, while too many leave damage, so the lab aims to understand how the 'right amount of DNA breaks' is controlled.
Crossover Position and Chromosome Segregation
C. elegans has holocentric chromosomes, in which the entire length of the chromosome functions as the kinetochore, and it segregates them by removing cohesin in two steps from the short and long arms separated by the crossover. The lab studies how positional information from the crossover leads to chromosome asymmetry.
MembersFaculty
The members of the Carlton Lab consist of faculty, postdoctoral researchers, graduate students, technical staff, and secretaries.
- Associate ProfessorCARLTON Peter-Mark
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