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Higher-Order Structure Dynamics Lab
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The lab investigates how cell-cell adhesion is regulated and repaired.
AboutAbout the lab
Understanding the body's homeostasis through cell adhesion
The Higher-Order Structure Dynamics Lab studies how adhesion between cells (cell-cell adhesion) is regulated in the epithelial tissues of multicellular organisms.
Epithelial tissues such as the skin and digestive tract are exposed to stresses such as damage, infection, inflammation, and changes in osmotic pressure, but the body's homeostasis is maintained because cell-cell adhesion is regulated and repaired.
Research centers on a new bioactive peptide, identified independently by the lab, that induces the formation of tight junctions.
The lab belongs to the Graduate School of Biostudies, and students join it at the graduate level.
Key terms
- Epithelial tissue
- A layer of cells covering the surface of the body and the inside of organs, such as the skin and the lining of the digestive tract
- Tight junction
- An adhesive structure that tightly seals the gap between neighboring epithelial cells
- Bioactive peptide
- A molecule made of a short chain of amino acids that triggers a specific function in the body
ResearchResearch themes
In multicellular organisms, cells adhere to one another to form tissues and maintain their functions. This lab studies the mechanisms that regulate cell-cell adhesion in epithelial tissues, aiming to understand how multicellular organisms are built, maintained, and repaired, and to control diseases caused by the breakdown of cell-cell adhesion and develop drugs.
View More ↗MembersFaculty
- ProfessorYukako Oda
- Program-Specific Assistant ProfessorKeigo Ogawa
- Program-Specific Assistant ProfessorAsako Kishimoto
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