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Systems Pharmacology Lab
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The lab seeks to understand the whole body as a system, starting from the mechanisms of sleep and wakefulness.
AboutAbout the lab
Using sleep and wakefulness as a model to understand how the whole body works
The Systems Pharmacology Lab studies the behavior of living organisms as a whole, using the rhythm of sleep and wakefulness as a clue.
The lab aims to understand "biological time," which links molecules, cells, individual organisms, and humans living in society.
The lab has independently developed a method for rapidly generating mutant mice, a method for making organs transparent for observation, and methods for measuring human sleep.
At the graduate level, students can join from either the Graduate School of Medicine or the Graduate School of Information Science and Technology.
Key terms
- Systems biology
- A field that seeks to understand the behavior of whole organisms from how parts such as genes and cells are connected
- Tissue clearing
- A technology that makes organs transparent with chemicals so that the cells inside can be observed intact, without sectioning
- Phosphorylation
- The attachment of a phosphate group to a protein; one of the mechanisms that switch protein function on and off
NewsLab news
Students received the Excellence Award at the University of Tokyo Life Science Symposium BIO UT
A student and a researcher received the Toshihiko Tokizane Memorial Award for Outstanding Doctoral Research in Neuroscience
Associate Professor Oide received the Best Teacher's Award from the University of Tokyo Faculty of Medicine
Published a paper reporting the analysis of all cells in the whole body using the tissue clearing technology CUBIC
A doctoral student received the Japan Society for the Promotion of Science (JSPS) Ikushi Prize
ResearchResearch themes
The lab aims to establish systems biology and pharmacology that extend to humans, using the rhythm of sleep and wakefulness as a model. To capture the connection between the levels of cells and individual organisms, it incorporates the ideas of systems science into its research.
*Illustrative imageGenerating mutant mice without crossbreeding
The lab developed a method to create mice in which genes are disrupted or inserted without repeated crossbreeding. It is working to establish this as next-generation mouse genetics.
*Illustrative imageMaking the whole body transparent to see cells
The lab established CUBIC, a tissue clearing technology that makes the brain and the whole body transparent and enables comprehensive examination down to individual cells. It is extending this work to high-speed imaging microscopes and to a foundation for data analysis.
*Illustrative imageTechnologies for measuring sleep
The lab has developed technologies that automatically determine sleep in mice from their breathing and brain waves. For humans, it created ACCEL, a method that distinguishes sleep from wakefulness using a wristwatch-type accelerometer.
*Illustrative imageThe phosphorylation hypothesis of sleep
The lab was the first to identify, in mammals, the kinases CaMKIIα/β that promote sleep. It proposes the "phosphorylation hypothesis of sleep," which holds that protein phosphorylation regulates sleep.
MembersFaculty
The Systems Pharmacology Lab consists of faculty members, project researchers, administrative and technical assistants, and graduate students, research students, and undergraduate students.As of 2026
- ProfessorHiroki UedaPublications ↗
- Associate ProfessorKoji Oide
- Assistant ProfessorMasaki Nagao
- Project Assistant ProfessorFukuaki Kinoshita
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lab mouse mg 3263” Rama / CC BY-SA 2.0 fr (cropped)
- Generating mutant mice without crossbreeding: “CRISPR-Cas9 Editing of the Genome ( )” National Human Genome Research Institute (NHGRI) / CC BY 2.0 (cropped)
- Making the whole body transparent to see cells: “3DISCO imaging of mouse brain” Fenerliabi11 / CC BY-SA 4.0 (cropped)
- Technologies for measuring sleep: “Actigraphy Device for Artemis II Human Health Study -- jsc2025e075542 alt” NASA Johnson Space Center / Helen Arase Vargas NASA-JSC / Public domain (cropped)
- The phosphorylation hypothesis of sleep: “Memory Molecule-Calcium Cadmodulin Dependent Kinase II (CamKII)” Mustafa Tekpinar / CC BY-SA 4.0 (cropped)
- Related lab (脳数理情報連携研究室): “Synapsin and CamK2 positive neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Related lab (数理生命情報学研究室): “Mouse Embryo Cerebellum ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (脳情報計測・
制御研究室(天野・中山研究室)): “Double cone coil” Baburov / CC BY-SA 4.0 (cropped) - Related lab (数理データ科学研究室): “Rosenbrock function 2” RokerHRO / Public domain (cropped)
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