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Ozeki Lab
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The lab uses lasers to detect molecular vibrations and rapidly visualize cells without staining them.
AboutAbout the lab
Innovative optical technologies for biology and medicine
The Ozeki Lab studies innovative optical technologies for biology and medicine.
Transparent biological samples usually cannot be observed unless they are stained with dyes or labeled with fluorescence, which is laborious.
The lab is developing stimulated Raman scattering microscopes that use state-of-the-art laser technology to detect molecular vibrations, allowing rapid observation without staining.
Rapid observation is needed in medical settings such as surgery, where tumor boundaries must be quickly distinguished from healthy tissue.
Key terms
- Stimulated Raman scattering
- A phenomenon in which, when the difference in frequency between two laser beams matches a molecular vibration, one beam is weakened and the other is strengthened
- Labeling
- A method of attaching a light-emitting marker (such as a fluorescent substance) to the molecule of interest so that it can be identified under a microscope
- Spectrum
- The distribution of light intensity when light is separated by color (wavelength). It provides clues about which molecules are present
NewsLab news
Prof. Ozeki elected as an Optica Fellow
Assistant Professor Kuruma received the 38th Hiroshi Ando Memorial Academic Encouragement Award
A doctoral student received the Outstanding Poster Presentation Award at the Fiber Laser Study Group
A doctoral student received the Outstanding Presentation Award at OPJ2024
A master's student received the Best Paper Award at MHS2024
ResearchResearch themes
The lab develops stimulated Raman scattering (SRS) microscopes that can rapidly image biological samples without staining or labeling. Its work covers laser technology that enables the next stage of imaging, image analysis that distinguishes biomolecules, and applications to biology and medicine.
*Illustrative imageHigh-speed multicolor Raman microscopy
This technique combines a video-rate SRS microscope with a wavelength-tunable pulsed light source to rapidly capture multicolor images of biological tissue without staining.
*Illustrative imageWavelength-tunable pulsed light source
Imaging works by matching the difference in frequency between two laser colors to a molecular vibration, so the lab develops pulsed light sources that can acquire spectra while changing the color (wavelength).
*Illustrative imageRaman spectrum analysis
The lab works on image analysis that identifies which biomolecules are located where, based on the acquired Raman spectra.
*Illustrative imageEasy-to-use fiber lasers
The lab studies practical fiber lasers that can be used as light sources for SRS microscopes.
MembersFaculty
The members of the Ozeki Lab consist of faculty, administrative assistants and technical assistants, project researchers, visiting researchers, academic specialists, collaborating researchers, doctoral students (including working-professional doctoral students), master's students, undergraduates, and interns.As of 2026
- ProfessorYasuyuki OzekiPublications ↗
- Associate ProfessorYoshitaka ShirasakiPublications ↗
- Assistant ProfessorKazuhiro KurumaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ti Sapph YAG supercontinnum” Neath g / CC BY-SA 4.0 (cropped)
- High-speed multicolor Raman microscopy: “HeLa-III” National Institutes of Health (NIH) / Public domain (cropped)
- Wavelength-tunable pulsed light source: “IR Optical Parametric Oscillator” Kkmurray / CC BY 3.0 (cropped)
- Raman spectrum analysis: “HeLa-I” National Institutes of Health (NIH) / Public domain (cropped)
- Easy-to-use fiber lasers: “Зеркало резонатора волоконного лазера в темноте (Resonator mirror of Er ZBLAN fiber laser and its working fiber in the dark)” Hius1 / CC BY 4.0 (cropped)
- Related lab (Matsui Lab): “Nanoscale Plasmonic Resonator Structures ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Yamashita-Set Lab): “Зеркало резонатора волоконного лазера в темноте (Resonator mirror of Er ZBLAN fiber laser and its working fiber in the dark)” Hius1 / CC BY 4.0 (cropped)
- Related lab (Takenaka Lab): “Silicon Photonics 300mm wafer” Ehsanshahoseini / CC BY-SA 4.0 (cropped)
- Related lab (Tanemura Lab): “"Lines made with light" - diffraction gratings at the UK ATC ( )” Science and Technology Facilities Council / CC BY-SA 2.0 (cropped)
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