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Life Energy Engineering Lab
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The lab explores the mechanics of biological tissues and materials for regenerative medicine through experiments and numerical analysis.
AboutAbout the lab
Solving biomechanics with materials and computation
The Life Energy Engineering Lab studies the mechanics of biological tissues such as bone and myocardium, and materials used in regenerative medicine.
The lab is developing a biodevice that beats autonomously by combining cardiomyocytes made from iPS cells with synthetic polymer materials.
In collaboration with clinical orthopedic surgeons, it also builds numerical models of bones and joints from clinical CT images and investigates how fractures occur using the finite element method.
On the lab's website, it is introduced under the name "Energy Conversion Engineering Field, Todo Lab."
Key terms
- iPS cells
- Pluripotent stem cells that can differentiate into many types of cells. Techniques for differentiating them into cardiomyocytes are well established.
- Finite element method
- A numerical analysis method that divides an object into small elements and computes how forces are applied and how the object deforms.
- Scaffold materials
- Materials that serve as a base when combined with cells to build tissue in regenerative medicine.
ResearchResearch themes
In collaboration with medical researchers, the lab investigates artificial materials used in the body and the mechanics of biological tissues such as bone and myocardium. It uses both experimental evaluation and stress analysis by the finite element method.
*Illustrative imageA beating device made from iPS cardiomyocytes
Combining iPS cell-derived cardiomyocytes with synthetic polymer materials, the lab is developing a biodevice that beats autonomously. In myocardial tissue, the chemical energy of ATP is converted into mechanical energy.
*Illustrative imageHydrogel batteries inspired by electric eel electrocytes
The lab aims to improve the performance and engineering applications of hydrogel batteries that mimic the power-generation mechanism of electrocytes in electric eels. It has found an electrolyte that produces a higher electromotive force than sodium chloride.
*Illustrative imageBone biomechanics from clinical CT images
In collaboration with clinical orthopedic surgeons, the lab builds 3D bone and joint models from clinical CT images. It applies fracture analysis combining the finite element method and damage mechanics to a variety of clinical problems.
*Illustrative imageDeveloping scaffold materials for regenerative medicine
The lab is developing cylindrical structures made of bioresorbable polymers and other materials for blood vessel regeneration, as well as porous structures for bone regeneration made by combining calcium phosphate-based bioceramics with biocompatible polymers.
MembersFaculty
The Life Energy Engineering Lab consists of faculty members, administrative assistants, doctoral and master's students, international students, and non-degree research students.As of 2019
- Associate ProfessorMitsugu Todo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cardiac Muscle Cells” Riveromonicadaniela / CC BY-SA 4.0 (cropped)
- A beating device made from iPS cardiomyocytes: “CSIRO ScienceImage 1521 iPS cells in the lab” , CSIRO / CC BY 3.0 (cropped)
- Hydrogel batteries inspired by electric eel electrocytes: “Electrophorus electricus 3” Stan Shebs / CC BY-SA 3.0 (cropped)
- Bone biomechanics from clinical CT images: “Femur (caput femoris) - bone structure detail (vertical cut) 2” MAKY.OREL / CC0 (cropped)
- Developing scaffold materials for regenerative medicine: “Micropear” Rob Pullar / CC BY 4.0 (cropped)
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- Related lab (新エネルギーシステム工学分野): “FBH GaN Leistungselektronik” FBH/P.Immerz / CC BY-SA 4.0 (cropped)
- Related lab (材料情報学分野): “Silver surface crystal growth SEM” Fernando Estel / CC BY-SA 3.0 (cropped)
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