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Biological Function Engineering Lab
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A lab that explores the functions of cells and blood cells from a biomechanics perspective.
AboutAbout the lab
Uncovering through mechanics how cells respond to force.
The Biological Function Engineering Lab studies various phenomena in living organisms from the perspectives of biomechanics and biotransport.
The lab seeks to clarify how the functions of cells and tissues adapt to changes in their mechanical environment, with the aim of applying this to areas such as regenerative medicine.
In addition, it investigates how substances are transported and move within the body at each level: proteins, cells and tissues, and whole organisms.
Key terms
- Biomechanics
- The field that studies the functioning of living bodies and cells using mechanical concepts such as force and deformation
- Biotransport
- Phenomena of transport and movement of substances within living organisms. Studied at each level, from proteins to whole organisms
- Cell migration
- The phenomenon of cells moving. It underlies cancer metastasis and the development of tissues and organs
- Hydrogel
- A gel made of polymers. This lab develops it with controlled physical properties as a substrate for culturing cells
NewsLab news
Professor Kudo receives the Bioengineering Division Achievement Award of the Japan Society of Mechanical Engineers
A press release is issued about Associate Professor Takeishi's paper in the Journal of Fluid Mechanics
A doctoral student receives a Research Encouragement Award at the Kyushu Branch Academic Lecture Meeting of the Japanese Society for Medical and Biological Engineering
ResearchResearch themes
The lab studies phenomena in living organisms from the perspectives of biomechanics and biotransport. It aims to clarify how cells and tissues adapt to changes in their mechanical environment and to apply this to areas such as regenerative medicine.
*Illustrative imageCancer Cells and Intracellular Transport
Focusing on the relationship between mechanical stimuli and intracellular transport, the lab measures the movement and localization of intracellular proteins in real time. By combining experimental observation with mechanical model analysis, it clarifies the relationship among mechanics, intracellular transport, and disease, aiming at next-generation therapeutic applications.
*Illustrative imageDirectional Cell Migration
The lab works to elucidate the mechanisms of directional cell migration, a form of cell migration with a set direction that underlies cancer metastasis and the development of tissues and organs. It examines the relationship between cell behavior under different substrate conditions and intracellular protein dynamics, aiming at applications in wound healing and regenerative medicine.
*Illustrative imageBiomimetic Materials That Control Cell Function
Cells change their metabolic activity, proliferation, and differentiation state according to the mechanical properties of their surroundings. Using polymer hydrogels with controllable physical properties, the lab develops cell culture substrates that can replace tissues in the body, aiming at applications in cancer treatment, regenerative medicine, and artificial organs.
*Illustrative imageNumerical Analysis of Blood Cell Flow and Mass Transport
In the microcirculation, inertial effects are almost negligible, so Stokes flow is a good approximation. Using numerical simulation to capture the detailed interactions in blood cell flow, the lab seeks to clarify problems related to convective mass transport in the microcirculation.
MembersFaculty
The members of the Biological Function Engineering Lab consist of faculty members and doctoral, master's, and undergraduate students.As of 2025
- ProfessorSusumu Kudo
- Associate ProfessorNaoki Takeishi
- Assistant ProfessorSaori Sasaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Red blood cell on glass” Rogeriopfm / CC BY-SA 3.0 (cropped)
- Cancer Cells and Intracellular Transport: “Brefeldin A Inhibition of Intracellular Vesicle Transport” Ahop28 / CC BY-SA 4.0 (cropped)
- Directional Cell Migration: “Fibroblast (BPAE)” Heiti Paves / CC BY-SA 3.0 (cropped)
- Biomimetic Materials That Control Cell Function: “Growing razors 01 inorganic layer growing on biomaterial” Jan Ozimek / CC BY 4.0 (cropped)
- Numerical Analysis of Blood Cell Flow and Mass Transport: “Blood Anemia” Jlabanimation / CC BY-SA 4.0 (cropped)
- Related lab (ヒューマンセンタードロボティクス研究室): “Shadow Hand Bulb large” Richard Greenhill and Hugo Elias (myself) of the Shadow Robot Company / CC BY-SA 3.0 (cropped)
- Related lab (構造材料評価研究室): “TiAl duplex” Lne / CC0 (cropped)
- Related lab (生体熱工学研究室): “Ultrasound (2)” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (設計工学研究室): “Prosthesis 002” National Institute of Standards and Technology / Public domain (cropped)
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