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Fluid Biomedical Engineering Lab
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A lab that uses engineering to investigate the functions of cells at the micro- and nanoscale.
AboutAbout the lab
Exploring biomedical applications at the micro- and nanoscale.
The Fluid Biomedical Engineering Lab studies biomedical applications at the micro- and nanoscale.
Drawing on knowledge of mechanical engineering, electrical engineering, medicine, and biology in microscale fluid environments, the lab aims to elucidate unknown functions of cells and to achieve healing at the cellular level.
It works on elucidating the mechanisms of unusual, high-speed phenomena that occur in time-varying electric fields and fluid fields, and on bringing about new functions in devices such as injectors, gene delivery technologies, and processing devices.
The "fluid" in the lab's name refers to multiphase fluids such as microbubbles, and the lab's website presents it under the name "Yamanishi Lab."
Key terms
- Electric field-induced bubbles
- Bubbles generated in liquid by electrical force. Used in research on a needle-free bubble injector
- Atmospheric-pressure low-temperature plasma
- Low-temperature plasma produced at atmospheric pressure. Technology to generate it inside bubbles in liquid is being established
- Radicals
- Highly reactive atoms or molecules. Transported over a distance by plasma bubbles, leading to the killing of cancer cells and other applications
NewsLab news
Research paper by Assistant Professor Naotomo Tottori published in Small
Paper by a graduate published in Biomedical Microdevices
An academic researcher received a Corporate Award at the 53rd Meeting of the Society for Chemistry and Micro-Nano Systems
Paper by a graduate published in Micromachines
Research results by doctoral students published in Sensors and Actuators B: Chemical
ResearchResearch themes
The lab aims to elucidate unknown functions of living cells and to achieve healing at the cellular level through an engineering approach. Its topics include technology that kills only targeted cancer cells, cell surgery in microscale spaces, and new gene delivery technology for controlling cell differentiation in regenerative medicine.
*Illustrative imageCell Processing and Gene Delivery
The lab performs cell processing and nuclear transfer using a phenomenon in which an electrical discharge in a tiny space inside a glass capillary fires a directional, high-speed train of bubbles. It also works on delivering reagents such as genes into hard targets and on high-precision gene delivery.
*Illustrative imageProtein Crystallization
High-resolution crystals are essential for protein structure analysis, but organic crystals have weak bonding forces between molecules and tend not to crystallize. The lab introduces factors that trigger crystallization by firing electric field-induced bubbles, and works on crystallizing proteins that could not be crystallized until now.
*Illustrative imageMedical Applications of Plasma Bubbles in Liquid
Using a technique that generates plasma inside bubbles in liquid with atmospheric-pressure low-temperature plasma, a new method of plasma generation, the lab works on biomedical applications. It is developing technology that transports highly reactive radicals over a distance, leading to the killing of cancer cells at targeted locations and the activation of cells.
MembersFaculty
Members of the Fluid Biomedical Engineering Lab include faculty, academic researchers, technical staff, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYoko Yamanishi
- Associate ProfessorShinya Sakuma
- Assistant ProfessorNaotomo Tottori
- Assistant ProfessorMakoto Saito
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pico Injection” Kimbalm / CC BY-SA 4.0 (cropped)
- Cell Processing and Gene Delivery: “Electroporation Cuvettes” Richard Wheeler en:User:Zephyris / CC BY-SA 3.0 (cropped)
- Protein Crystallization: “Protein Crystal Growth Porcine Elastase” 作者不詳 / Public domain (cropped)
- Medical Applications of Plasma Bubbles in Liquid: “Reflection in a soap bubble edit” Brocken Inaglory. The image was edited by user:Alvesgaspar / CC BY-SA 3.0 (cropped)
- Related lab (生体熱工学研究室): “Ultrasound (2)” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (先端医療デバイス研究室): “Surgeon performing robot-assisted surgery” Navy Medicine / Public domain (cropped)
- Related lab (材料創製力学研究室): “JEOL JEM-200A transmission electron microscope -14” High Contrast / CC BY 3.0 de (cropped)
- Related lab (ヒューマンセンタードロボティクス研究室): “Shadow Hand Bulb large” Richard Greenhill and Hugo Elias (myself) of the Shadow Robot Company / CC BY-SA 3.0 (cropped)
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