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Biological Energy Engineering Lab
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A biomechanics lab that uses engineering to study the mechanics of heart cells and bone.
AboutAbout the lab
Explaining how the heart and bones work through mechanics.
The Biological Energy Engineering Lab studies biological tissues such as heart cells and bone using methods from mechanics.
The lab is developing devices that beat using cardiomyocytes made from iPS cells, and is also using CT images to study the strength of bone and how it fractures.
It also works on hydrogel batteries that mimic the power-generating mechanism of electric eels, and on developing scaffold materials for regenerative medicine.
On the lab's website, it is introduced under the name "Todo Lab."
Key terms
- iPS cells
- Pluripotent cells that can differentiate into a wide variety of cell types
- Regenerative medicine
- A medical approach that replaces damaged organs or tissues with ones close to the original, rather than with artificial substitutes
- Osteoporosis
- A condition in which the bone structure becomes fragile and fractures occur easily
ResearchResearch themes
The lab studies heart cells, bone, and materials for regenerative medicine using methods from engineering mechanics. In collaboration with orthopedic clinicians, it also analyzes bone using clinical CT images.
*Illustrative imageDevices that beat with iPS cell-derived cardiomyocytes
The lab combines iPS cell-derived cardiomyocytes with synthetic polymer materials to develop biodevices that beat autonomously. In heart muscle, stored chemical energy is converted into mechanical energy.
*Illustrative imageHydrogel batteries modeled on electric eels
The lab aims to improve the performance and expand the applications of hydrogel batteries that mimic the electricity-generating cells of electric eels, which a University of Michigan group demonstrated in 2017. It has found an electrolyte that produces a higher electromotive force than sodium chloride.
*Illustrative imageBone biomechanics studied with CT images
In collaboration with orthopedic clinicians, the lab builds 3D bone and joint models from clinical CT images and analyzes fractures by combining the finite element method with damage mechanics. It applies this work to clinical problems related to osteoporosis and artificial joints.
*Illustrative imageDeveloping scaffold materials for regenerative medicine
The lab develops cylindrical structures made of bioabsorbable polymers for blood vessel regeneration, and porous structures for bone regeneration that combine calcium phosphate-based bioceramics with biocompatible polymers.
MembersFaculty
The lab's members consist of faculty members, administrative assistants, doctoral and master's students, international students, and research students.As of 2019
- Associate ProfessorMitsugu Todo
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Yeast cultures in incubator-2” Masur / CC BY-SA 4.0 (cropped)
- Devices that beat with iPS cell-derived cardiomyocytes: “Cardiovascular system - Cardiac muscle cells -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Hydrogel batteries modeled on electric eels: “Electrophorus electricus 7zz” Photo by David J. Stang / CC BY-SA 4.0 (cropped)
- Bone biomechanics studied with CT images: “Trabecular Bone Mouse Compared Spaceflight And Ground” NASA, image from Marshall Space Center / Public domain (cropped)
- Developing scaffold materials for regenerative medicine: “3D printed Hydrogel Scaffold” Habannn / CC0 (cropped)
- Related lab (Materials Electrochemistry Lab): “All-solid lithium-sulfur battery ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (Nonlinear Physics Lab): “TFF Double pendulum” Jedidiah T-F / CC0 (cropped)
- Related lab (Functional Inorganic Materials Engineering Lab): “Ceramic monoliths” S. Govender, H. Friedrich / CC BY-SA 4.0 (cropped)
- Related lab (Building Environmental Engineering Lab): “Buildings in Orekhovo-Zuevo. Ventilation on the roof of the building 02” Dmitry Makeev / CC BY-SA 4.0 (cropped)
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