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Functional Organization Chemistry Lab
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The lab uses chemistry to develop drug delivery, diagnostics, and cell-based therapeutics.
AboutAbout the lab
Thinking flexibly under the motto "Chemistry for Medicine".
The Functional Organization Chemistry Lab studies therapeutic and diagnostic technologies under the motto "Chemistry for Medicine."
Its themes include mechanisms for delivering drugs to disease sites, more precise cancer diagnosis, cell-based medicine that uses cells themselves as drugs, and drugs that suppress excessive immune responses such as allergies.
The lab brings together people from diverse backgrounds, including chemistry, molecular biology, pharmacy, medicine, and veterinary medicine.
On the lab's website, it is introduced under the name "Katayama Lab."
Key terms
- Human cell-orthogonal enzyme
- An enzyme that does not function the same way as enzymes in human cells. In analysis, it can increase the signal while keeping background reactions low.
- Endogenous antibody
- An antibody that the body naturally has, abundant in the blood.
- Macrophage
- A type of immune cell.
- Stealth polymer
- A biocompatible polymer. This lab aims to develop one that can replace PEG.
NewsLab news
Assistant Professor Teruki Nii received the Science Encouragement Award from the Japanese Society for Biomaterials
Assistant Professor Teruki Nii received the Best Presentation Award from The Korean Society for Biomaterials
Assistant Professor Teruki Nii received the Japan-Korea Biomaterials Society Young Researcher Exchange Award
Assistant Professor Teruki Nii received the top prize at the Fukuoka Bio Community's FBCAP
ResearchResearch themes
Under the motto "Chemistry for Medicine," the lab thinks flexibly to meet needs. It works on multiple themes, including cancer diagnosis, cancer therapy using antibodies and cells, and polymers to replace PEG.
*Illustrative imagePrecise diagnosis with enzymes absent from human cells
The lab pioneered human cell-orthogonal enzymes as a technology for capturing slight differences between cancer cells and normal cells. It synthesizes substrates that respond to these enzymes, aiming at single-cell analysis and screening of signal responses in cell populations.
*Illustrative imageCancer therapy using endogenous antibodies
Antibody drugs are costly to produce and have high immunogenicity. The lab therefore attempted to develop a new cancer therapy that uses endogenous antibodies, which are abundant in the blood, instead of antibody drugs.
*Illustrative imageMaking macrophages into drugs
The lab focuses on macrophages, a type of immune cell, and is developing "macrophage medicine," which uses them as drugs. By designing cells based on their native functions and adding new functions, it aims to develop treatments for cancer and chronic diseases.
*Illustrative imageStealth polymers to replace PEG
PEG has low biotoxicity and stays in the blood for a long time, so it has been used in nanomedicine and biopharmaceuticals. In recent years, more people are reported to have antibodies against PEG, and the lab aims to develop biocompatible polymers as an alternative.
MembersFaculty
The Functional Organization Chemistry Lab consists of faculty members, postdoctoral researchers, doctoral and undergraduate students, research students, and administrative assistants.
- ProfessorTakeshi Mori
- Assistant ProfessorTeruki Nii
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Macrophage (NIH BioArt 313)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Precise diagnosis with enzymes absent from human cells: “Pathologists looking into microscopes (1)” Linda Bartlett (Photographer) / Public domain (cropped)
- Cancer therapy using endogenous antibodies: “Peptide bound to Rituximab FAB” Simon Caulton / CC BY-SA 3.0 (cropped)
- Making macrophages into drugs: “Macrophage (NIH BioArt 309)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Stealth polymers to replace PEG: “Polyethylene glycol 4000” Anypodetos / CC0 (cropped)
- Related lab (安田研究室
（高等研究院） ): “OLED SUBPIXELS” TECH EDU / CC BY-SA 4.0 (cropped) - Related lab (分子システム化学研究室): “Lipid-like and protein-like self-assembly” Shenyu Yang, Yun Yan, Jianbin Huang, Andrei V. Petukhov, Loes M. J. Kroon-Batenburg, Markus Drechsler, Chengcheng Zhou, Mei Tu, Steve Granick & Lingxiang Jiang / CC BY 4.0 (cropped)
- Related lab (マテリアルズインフォマティクス研究室): “Molecular docking” Diego Mariano / CC BY-SA 4.0 (cropped)
- Related lab (分子情報システム研究室): “Three examples of partitioning carbon nanotubes in liquid phases ( )” National Institute of Standards and Technology / Public domain (cropped)
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