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Artificial Enzyme Chemistry Lab
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A lab that learns from enzymes and antibodies to create highly functional molecules and materials.
AboutAbout the lab
Learn from living systems, and surpass them.
The Artificial Enzyme Chemistry Lab learns from proteins such as enzymes and antibodies, and aims to realize materials, catalysts, and devices that show the high functionality of living systems.
Using organic synthesis techniques, the lab studies plastic antibodies, CO2 separation materials, catalysts inspired by living systems, and dyes and photofunctional materials, with the aim of helping solve problems in the environment, energy, and medicine.
The lab accepts many students advancing from other universities and colleges of technology (KOSEN).
On the lab's website, the lab is listed as the "Hoshino Lab."
Key terms
- Plastic antibody
- A synthetic polymer nanoparticle that, like an antibody, binds strongly to a specific molecule
- Precision polymer
- A polymer whose molecular weight and sequence are fully defined. It became possible to synthesize through advances in polymerization and purification techniques
- Thermocell
- A battery that uses a temperature difference. The lab is developing one using gel particles whose properties change with temperature
NewsLab news
A master's student won a Poster Award at the 2026 Symposium on Photochemistry
A doctoral student won the TCI Poster Award at the 36th Symposium on Physical Organic Chemistry
A master's student won an Outstanding Poster Award at the 2nd Area Meeting of Transformative Research Areas (A)
A doctoral student won a Best Presentation Award at the 9th Student Seminar
Students won multiple awards at the 63rd Joint Kyushu Conference of Chemistry-Related Chapters
ResearchResearch themes
The lab learns from living systems and draws on organic synthetic chemistry, coordination chemistry, photochemistry, and polymer chemistry to create molecules, materials, and devices that have high functionality like antibodies, enzymes, and cells. Its current focus is the creation and functional development of artificial antibodies, thermocells, CO2 separation materials, CO2 conversion catalysts, environmental remediation catalysts, and photofunctional materials.
*Illustrative imageDevelopment of Plastic Antibodies
The lab develops "plastic antibodies," synthetic polymer nanoparticles that, like antibodies, bind strongly to specific molecules. It has created nanoparticles that recognize target peptides and proteins, and has also shown that they can neutralize the toxicity of antigens in the bodies of animals.
*Illustrative imageNext-Generation Medicines from Precision Polymers
By combining synthesis technology for precision polymers, whose molecular weight and sequence are fully defined, with techniques such as directed molecular evolution and in silico drug discovery, the lab aims to create a new academic field, "polymer evolutionary engineering." This work is carried out jointly with the University of Tokyo, Tokyo Institute of Technology, and the University of Shizuoka.
*Illustrative imageThermocells and CO2 Separation Materials
Using the property of gel particles whose volume changes in response to temperature, the lab develops thermocells and CO2 separation materials. It found that gel particles with introduced amine groups reversibly absorb and release CO2 with only a small temperature difference.
*Illustrative imageDevelopment of Catalysts Inspired by Living Systems
The lab works on the molecular design of artificial enzymes using biologically relevant metal complexes, and on developing organic reactions driven by renewable energy. It aims to merge chemistry and the environment, including resource recycling, environmental remediation, and converting carbon dioxide into resources.
MembersFaculty
The Artificial Enzyme Chemistry Lab consists of faculty, technical staff, administrative assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYu Hoshino
- ProfessorHisashi Shimakoshi
- Associate ProfessorToshikazu Ono
- Project Associate ProfessorYusuke Yonamine
- Assistant ProfessorYukiko Nagai
- Assistant ProfessorSotaro Tsuji
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rubber bung with flask” Nadans. / CC BY-SA 4.0 (cropped)
- Development of Plastic Antibodies: “Antibody IgG1 surface” Tokenzero / CC BY-SA 4.0 (cropped)
- Next-Generation Medicines from Precision Polymers: “Polymer implant eluting drugs” Skyecaitlin258 / CC BY-SA 4.0 (cropped)
- Thermocells and CO2 Separation Materials: “Thermogalvanic cell General” Valaratar / CC BY-SA 3.0 (cropped)
- Development of Catalysts Inspired by Living Systems: “Enzymes -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (グリーンケミストリー研究室): “Laboratory Glassware” Michael Pereckas from Milwaukee, WI, USA / CC BY 2.0 (cropped)
- Related lab (有機機能分子化学研究室): “Organic Chemistry Lab by marthou” Marthou / CC BY-SA 4.0 (cropped)
- Related lab (反応・物性理論研究室
（先導物質科学研究所） ): “L-menthol-3D-molecular-model-engraved-render-CAS” MolGod Scientific / CC BY-SA 4.0 (cropped) - Related lab (機能材料化学研究室): “Soviet K73-9 film capacitors, 1984 - surface decomposing 05(DXO)” Retired electrician / CC0 (cropped)
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