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Bionanotechnology Lab
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The lab reads the sequences of DNA and other molecules by examining single molecules with nanoscale electrodes and pores.
AboutAbout the lab
Reading biomolecule sequences with single-molecule analysis technology
The Bionanotechnology Lab (Taniguchi Lab) studies single-molecule science, which uses nanodevices to examine the electrical conductance, temperature, structure, and other properties of a single molecule.
Combining nanotechnology, quantum measurement, AI, and biology, the lab is developing fifth-generation sequencers that directly read the base sequences of DNA and RNA and the amino acid sequences of proteins.
The lab uses this sequencer to discover new cancer markers and is developing methods for early cancer diagnosis.
Going forward, the lab will also begin research to find trace amounts of antibodies and antigens in the body and to create drugs for cancer and intractable diseases.
Key terms
- Sequencer
- A device that reads the base sequences of DNA and RNA and the amino acid sequences of proteins
- Nanogap
- An electrode pair with a gap of about 1 nanometer. When a molecule enters the gap, the amount of tunneling current changes depending on the type of molecule
- Nanopore
- An extremely small hole made in a silicon substrate. When a substance enters, it obstructs the flow of ions and the current temporarily decreases
NewsLab news
View More ↗ResearchResearch themes
This lab develops single-molecule analysis technologies that use nanodevices made with nanotechnology to examine the electrical conductance, temperature, heat, structure, and other properties of a single molecule. Applying these technologies, it is developing single-molecule DNA/RNA sequencers and single-molecule structure analysis methods that will support personalized medicine.
*Illustrative imageMicrofabrication below 10 nm
The lab develops techniques to make nanogaps, which are electrode gaps narrower than 10 nm, and nanopores, which are holes less than 10 nm in diameter. By combining electron beam lithography with semiconductor fabrication technology, it produces identical structures with high reproducibility.
*Illustrative imageElectrodes that identify biomolecules at the single-molecule level
A voltage is applied to electrodes with a gap of about 1 nanometer, and changes in the resulting tunneling current are measured. The lab develops technology to detect biomolecules such as DNA, RNA, peptides, and neurotransmitters one molecule at a time and to identify their type.
*Illustrative imageIdentifying viruses and bacteria with nanopores and AI
Changes in current as a substance enters a nanopore are distinguished by training AI on a large number of waveforms. The lab builds nanopores suited to each detection target and studies how to identify viruses and bacteria one by one.
MembersFaculty
The members of the Bionanotechnology Lab consist of faculty members, Project Professors, project researchers, secretaries, visiting professors, visiting researchers, master's students, and research students.As of 2025
- ProfessorMasateru Taniguchi
- Associate ProfessorMakusu Tsutsui
- Associate ProfessorTakahito Oshiro
- Assistant ProfessorHiroyuki Tanaka
- Assistant ProfessorYuki Komoto
- Project ProfessorTakashi Washio
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Nanopore-based single molecule mass spectrometry ( )” National Institute of Standards and Technology / Public domain (cropped)
- Microfabrication below 10 nm: “Nanopore Sequencing ( )” National Human Genome Research Institute (NHGRI) from Bethesda, MD, USA / CC BY 2.0 (cropped)
- Electrodes that identify biomolecules at the single-molecule level: “DNA Sequencing Method ( )” National Institute of Standards and Technology / Public domain (cropped)
- Identifying viruses and bacteria with nanopores and AI: “Colorized transmission electron micrograph of monkeypox virus particles (green)” National Institute of Allergy and Infectious Diseases (NIAID) / CC BY 2.0 (cropped)
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